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Find a comprehensive guide to possible side effects including common and rare side effects when taking Effexor (Venlafaxine Hydrochloride) for healthcare. Outpatient Administration of Intravenous Therapies in Patients with HIV Infection: HIV InSite Knowledge Base Chapter October 2004; Content reviewed February 2006. Dengue fever (breakbone fever) is a disease transmitted by a mosquito bite. Read about dengue treatment and symptoms, like rash and high fever, get vaccine.
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FDA prescribing information, side effects and uses. Generic Name: venlafaxine hydrochloride. Dosage Form: tablets. Effexor®(venlafaxine hydrochloride)Tablets.
Rx only. Suicidality and Antidepressant Drugs. Antidepressants increased the risk compared to placebo of suicidal thinking and behavior (suicidality) in children, adolescents, and young adults in short- term studies of Major Depressive Disorder (MDD) and other psychiatric disorders. Anyone considering the use of Effexor or any other antidepressant in a child, adolescent, or young adult must balance this risk with the clinical need. Short- term studies did not show an increase in the risk of suicidality with antidepressants compared to placebo in adults beyond age 2.
Depression and certain other psychiatric disorders are themselves associated with increases in the risk of suicide. Patients of all ages who are started on antidepressant therapy should be monitored appropriately and observed closely for clinical worsening, suicidality, or unusual changes in behavior. Families and caregivers should be advised of the need for close observation and communication with the prescriber. Effexor is not approved for use in pediatric patients. See WARNINGS: Clinical Worsening and Suicide Risk, PRECAUTIONS: Information for Patients, and PRECAUTIONS: Pediatric Use)DESCRIPTIONEffexor (venlafaxine hydrochloride) is a structurally novel antidepressant for oral administration. It is designated (R/S)- 1- [2- (dimethylamino)- 1- (4- methoxyphenyl)ethyl] cyclohexanol hydrochloride or (±)- 1- [α- [(dimethyl- amino)methyl]- p- methoxybenzyl] cyclohexanol hydrochloride and has the empirical formula of C1.
H2. 7NO2 HCl. Its molecular weight is 3. The structural formula is shown below. Venlafaxine hydrochloride is a white to off- white crystalline solid with a solubility of 5. L in water (adjusted to ionic strength of 0.
M with sodium chloride). Its octanol: water (0. M sodium chloride) partition coefficient is 0. Compressed tablets contain venlafaxine hydrochloride equivalent to 2. Inactive ingredients consist of cellulose, iron oxides, lactose, magnesium stearate, and sodium starch glycolate.
CLINICAL PHARMACOLOGYPharmacodynamics. The mechanism of the antidepressant action of venlafaxine in humans is believed to be associated with its potentiation of neurotransmitter activity in the CNS. Preclinical studies have shown that venlafaxine and its active metabolite, O- desmethylvenlafaxine (ODV), are potent inhibitors of neuronal serotonin and norepinephrine reuptake and weak inhibitors of dopamine reuptake.
Venlafaxine and ODV have no significant affinity for muscarinic, histaminergic, or α- 1 adrenergic receptors in vitro. Pharmacologic activity at these receptors is hypothesized to be associated with the various anticholinergic, sedative, and cardiovascular effects seen with other psychotropic drugs. Venlafaxine and ODV do not possess monoamine oxidase (MAO) inhibitory activity. Pharmacokinetics. Venlafaxine is well absorbed and extensively metabolized in the liver.
O- desmethylvenlafaxine (ODV) is the only major active metabolite. On the basis of mass balance studies, at least 9. Approximately 8. 7% of a venlafaxine dose is recovered in the urine within 4. ODV (2. 9%), conjugated ODV (2.
Renal elimination of venlafaxine and its metabolites is the primary route of excretion. The relative bioavailability of venlafaxine from a tablet was 1. Food has no significant effect on the absorption of venlafaxine or on the formation of ODV. The degree of binding of venlafaxine to human plasma is 2.
L. The degree of ODV binding to human plasma is 3. L. Protein- binding- induced drug interactions with venlafaxine are not expected. Steady- state concentrations of both venlafaxine and ODV in plasma were attained within 3 days of multiple- dose therapy.
Venlafaxine and ODV exhibited linear kinetics over the dose range of 7. Plasma clearance, elimination half- life and steady- state volume of distribution were unaltered for both venlafaxine and ODV after multiple- dosing. Apps Adults'>Apps Adults. Free Maths Lessons For Adults.
Mean ± SD steady- state plasma clearance of venlafaxine and ODV is 1. L/h/kg, respectively; elimination half- life is 5 ± 2 and 1. L/kg and 5. 7 ± 1. L/kg, respectively. When equal daily doses of venlafaxine were administered as either b. AUC) and fluctuation in plasma levels of venlafaxine and ODV were comparable following both regimens.
Age and Gender. A pharmacokinetic analysis of 4. ODV were unaltered due to age or gender differences. Dosage adjustment based upon the age or gender of a patient is generally not necessary (see DOSAGE AND ADMINISTRATION). Liver Disease. In 9 subjects with hepatic cirrhosis, the pharmacokinetic disposition of both venlafaxine and ODV was significantly altered after oral administration of venlafaxine. Venlafaxine elimination half- life was prolonged by about 3.
ODV elimination half- life was prolonged by about 6. A large degree of intersubject variability was noted.